“PupilMetrics Research” and “PupilMetrics Neuro” implements Professor Bryan K. Marcia’s clinical and historical research protocols.   Core Algorithm Components  
  1. Iris Detection
 
  • Uses grayscale image processing to locate the iris boundary
  • Employs a circle-scoring algorithm that searches for the strongest edge gradient
  • Two-pass detection: coarse search followed by fine refinement
  • Returns center coordinates, radius, and confidence score
 
  1. Pupil Detection
 
  • Searches within the inner portion of the detected iris
  • Uses adaptive thresholding based on the darkest 30% of pixels
  • Fits an ellipse to the dark region using covariance matrix eigenvalue decomposition
  • Extracts boundary points by ray-casting from center outward
  • Returns center, major/minor axes, orientation angle, and boundary points
 
  1. Pupil Boundary Analysis
 
  • Analyzes 72 boundary points (every 5 degrees) around the pupil edge
  • Calculates deviation from the average radius at each clock position
  • Groups deviations by clock hour (12 zones)
  • Identifies flattenings (inward deviations) and protrusions (outward deviations)
 
  1. ANW (Autonomic Nerve Wreath) Detection (Current Phase)
 
  • Searches for gradient changes between pupil edge and mid-iris
  • Identifies the collarette boundary
  • Calculates ANW ratio relative to iris diameter
  • Algorithm updates include:
  • SHIFTS (Drawing Out) Which zone the collarette bulges toward Clinical correlation based on Velhover
  • CONSTRICTIONS (Drawing In) Frontal zone constricted S: Middle-temporal shift. ← Drawing OUT (protrusion), S: Frontal and basal zones are constricted. ← Drawing IN (narrowing) (ML detected 78% of pathological cases!) Basal zone constricted Combined “Frontal and basal” pattern Both in Same Eye Correctly reports both when present Matches Bexel output format exactly What We Now Have: ANW Ratio – Bexel-compatible calculation (25-35% normal) ANW Form Type – Regular, Drawn In, Drawn Out ANW Asymmetry – Per-sector variance detection Zone Constrictions – “Frontal zone constricted” style reporting Pattern Correlation – Compare pupil and ANW findings by sector
  Key Measurements Produced  
Parameter Description Normal Range
P/I Ratio Pupil diameter as % of iris diameter 20-30%
Ellipseness Minor/major axis ratio >95% normal
Circularity How circular the pupil boundary is >95% normal
Decentralization Pupil center offset from iris center <5% normal
Deformation Maximum boundary deviation <5% normal
ANW Ratio Autonomic nerve wreath position 25-35% normal
  Clinical Interpretation Features   Pupil Form Types applied in Velchover system (PupilMetrics Neuro Version)  
  • Circle – Normal
  • Oval-Vertical – Circulatory cerebral disturbances with danger of hemorrhage
  • Oval-Horizontal – Depressive states, atherosclerosis, asthma predisposition
  • Oval-Diagonal – Urogenital system disturbances
  • Left Oblique Ellipse – Urogenital weakness, possible left side paralysis
  • Unilateral Ellipse – Nervous asthma, bronchus difficulties
  • Ventral Diverging Ellipse – Leg motility issues, nervous system disturbances
  • Frontal Diverging Ellipse – Brain insult risk, anxiety, muscle spasms
  Decentration Patterns  
  • Frontal – Mental/cerebral issues
  • Basal – Leg motility, nervous system
  • Nasal – Lung pathology (right eye) / Cardiac issues (left eye)
  • Temporal – Nephritis, orchitis, salpingitis
  • Middle-Nasal – Oxygen deficiency, cardiospastic risk
  • Upper-Nasal – Mental disorders, spinal irritation
  • And 8 more NEW machine learning directional patterns…
  Zone-Specific Organ Associations   Each of the 8 pupil zones has specific organ associations for:  
  • Flattenings – Indicating hypofunction/weakness
  • Protrusions – Indicating hyperfunction/irritation
  Velhover’s Clinical Collarette Correlation Update 01.26.26   Shift Pattern Eye Clinical Association Middle-temporal shift OS (Left) Left ventricle overload, cardiac Lower temporal shift Either Vena cava inferior hemodynamics Middle-nasal shift Either Vagus/stellate ganglion hypofunction Basal shift Either Pelvic congestion, inflammatory diseases Upper temporal shift Either Vertebro-basilar insufficiency ·  Shifts (e.g., “S: Middle-temporal shift.”) ·  Constrictions (e.g., “Frontal zone constricted”) ·  Form Type (Regular, Drawn In, Indented, Lacerated) ·  Ratio Status (Spastic/Normal/Atonic) ·  Asymmetry % with Normal/Pathology label ·  Findings list   Main Application Features   Analysis Screen  
  • Real-time eye validation before analysis
  • Progress indicator during processing
  • Displays all measurements with color-coded status
  • Shows organ associations for detected anomalies
  • Full descriptions for Pupil Form and Decentration Patterns
  Reports Generated  
  1. On-Screen Results – Interactive cards with expandable details
  2. TXT Report – Plain text with results section
  3. JSON Report – Structured data for integration/archival
  4. PDF Report – Professional formatted document with images
  Additional Features  
  • Now available in eight languages EN,ES,PT,DE,FR,IT,KR,JP
  • Age-based pupil size assessment
  • Bilateral comparison between eyes
  • Scan history with database storage
  • PLR (Pupillary Light Reflex) video analysis
  • Anisocoria detection with TBI (Traumatic Brain Injury) indicator (Neuro-Version only)
 

Download and Install PupilMetrics Windows 64Bit Version